The future of vaccinations begins with trust – and trust is built through individuality and personalized vaccination strategies.
Every person is unique and our immune system is a complex interplay of genetics, microbiome, environmental factors and metabolic processes.
Modern medicine has made remarkable progress and vaccinations remain one of its greatest achievements. However, while medications are increasingly tailored to individual needs, vaccinations are still largely seen as a universal concept, often failing to consider personal health factors adequately.
Why shouldn’t vaccinations also be personalized?
Current vaccination strategies often overlook genetic predispositions, existing viral infections, vitamin D and folate deficiencies and microbiome imbalances, which can significantly impact immune responses. These factors may lead to unexpected side effects — yet preemptive diagnostics could help mitigate such risks.
The reality today
🌍 Declining global vaccination rates – Millions remain unvaccinated due to doubts, misinformation and lack of trust.
⚠️ Societal division – Families and friendships have fractured over vaccine debates.
💰 Rising healthcare costs – Emergencies, hospitalizations, and expensive diagnostics could have been prevented with simple pre-vaccine assessments.
Science is already paving the way
🔬 Advances in neoantigen vaccine research for personalized cancer immunization. (1, 2)
🧬 AI-supported vaccine development to optimize individual immune responses. (3)
📖 Studies like "Towards Personalized Vaccines" and "Advancements in mRNA Vaccines" highlight the future of tailored vaccine strategies.
It’s time for a revolution in vaccine medicine. Only by embracing personalized health profiles can we make vaccinations safer and more trusted. (4, 5)
Please calculate what a vitamin D and folate level test, a check of EBV (CMV, HHV), total IgM, CRP, microbiome and a standard PGx test (2C19, 2D6, 1A2, NAT2, ABC, GST deletions, SOD2, MTHFR) would have cost and what unbelievably high and truly exploding healthcare costs were subsequently incurred by not considering individual risk factors (emergency, hospital costs, emergency services, specialists, expensive genetic examinations e.g. multiple sclerosis, Fabry's disease, suspected rheumatoid arthritis, MRI and X-ray examinations, extensive and expensive laboratory tests), not to mention my own personal suffering and absence from work.
Personalized vaccination strategies are not a luxury – they are the future of modern healthcare.
Personalized vaccination strategies - Our immune system is not a static model. Only by taking personalized immune profiles seriously can we make vaccinations truly safe and effective.
I have created an ecosystem. (the better resolution of the representation can be found in the link)
Personalized vaccination strategies: 360-degree approaches
(1) https://www.mdpi.com/2673-6411/5/2/5 "Advances in Personalized Cancer Vaccine Development: AI Applications from Neoantigen Discovery to mRNA Formulation" by Hyunseung Kong, BioChem 2025, 5
(2), 5, Submission received: 25 February 2025 / Revised: 25 March 2025 / Accepted: 28 March 2025 / Published: 31 March 2025
(2) https://link.springer.com/article/10.1007/s10238-024-01436-7, "Personalized neoantigen cancer vaccines: current progression, challenges and a bright future", Da-Wei Wu at. all, Volume 24, article number 229, (2024)
(3) https://digitaldefynd.com/IQ/ai-in-vaccine-development-distribution/
(4) https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2024.1436108/full - "Towards personalized vaccines" Davide Montin at All, Front. Immunol., 03 October 2024, Sec. Vaccines and Molecular Therapeutics, Volume 15 - 2024 | https://doi.org/10.3389/fimmu.2024.1436108
(5) https://www.mdpi.com/2076-393X/12/8/873 "Recent Advancements in mRNA Vaccines: From Target Selection to Delivery System", by Zhongyan Wu / Weilu Sun and Hailong Qi, Vaccines 2024, 12(8), 873; https://doi.org/10.3390/vaccines12080873, Submission received: 24 June 2024 / Revised: 31 July 2024 / Accepted: 31 July 2024 / Published: 1 August 2024